Population genetic thesis

The model seeks to explain population declines of R. The study was led by Nicolas Alcala. The paper determines for a diploid coalescent model the time to the most recent common ancestor, both for two haplotypes in the same individual and for two haplotypes in different individuals. The work provides theory that builds on empirical observations in an earlier study [ ].

He shows that for biallelic markers whose mean frequency across a set of populations is fixed, these three statistics achieve their maximal values at the same configuration of allele frequencies across populations. The results extend Nicolas's earlier work on F ST bounds as well as that of two other studies from the lab concerning bounds on F ST [ ] [ ].

Compact coalescent histories represent a combinatorial structure that collapses standard coalescent histories into a smaller number of equivalence classes.

The study extends the lab's work on enumeration of coalescent histories to a new structure. The paper builds from the models developed by Ph. Jaehee Kim , Filippo Disanto , and Naama Kopelman report a study of the properties of the neighbor-joining algorithm when applied to data from admixed populations. The study shows that tree properties conjectured by Kopelman et al. Filippo Disanto examines the number of nonequivalent ancestral configurations for matching gene trees and species trees.

Here, Filippo shows that asymptotic growth for nonequivalent configurations is also exponential. This pair of studies extends the lab's work on theory of admixture and combinatorics of evolutionary trees. Arbisser's wise words about making hard decisions, such as square root transformation vs. Cailliez constant in multidimensional scaling: "it's important to consider what choices we're making and the consequences of those choices.

This analysis demonstrates that people typed with microsatellites used in forensic genetics can be connected to close relatives typed with single-nucleotide polymorphisms used in biomedical, genealogical, personal-genomic, and population-genetic studies.

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The characterization of these "lonely" pairs relies on the way in which the taxa contained in cherries of the gene tree are placed with respect to the root of the species tree. He examines combinatorial and probabilistic aspects of genealogical lineages along the branches of species trees, mathematical properties of F ST statistics in relation to homozygosities and haploypes, and a gene-culture coevolutionary model of health-related behaviors.

Congrats Rohan! Alan Aw reports a study in the Journal of Mathematical Biology , on the bounds on homozygosity and entropy statistics that measure genetic diversity in terms of the frequency of the most frequent allele. Alan uses the theory of majorization to obtain the bounds, generalizing previous mathematical results from the lab [ 52 ] [ 87 ].

Population Genetics

Amy Goldberg and Lawrence Uricchio report an overview of the literature on natural selection in human populations in an Oxford Bibliographies article. A commentary on Anthony Edwards's essay of multivariate classification of individuals into populations on the basis of genetic markers appears in a new book edited by Rasmus Winther about Edwards's career and contributions.

Among other topics, the commentary discusses the influence of Edwards's model on a phenotypic model from the lab [ ]. The study also includes simulations describing the effect of population growth and population subdivision on the relationship between tree height and tree length.

NERC Biomolecular Analysis Facility - Sheffield

PhD graduate Ethan Jewett contributed to the project. The initial data for these microsatellites suggested they were suitable for individual genotyping and characterization of B. A method of decreasing inhibiting factors present in lichen cells is also provided. In Chapter 4 regional genetic differentiation was revealed by an analysis using microsatellite markers developed in Chapter 3 over 11 populations in five regions of the Ross Sea Region.

The identification of three populations with high allelic richness and sites of high dispersal indicated three regions as putative refugia Terra Nova Bay, Dry Valleys and Beardmore Glacier. Terra Nova Bay has not previously been highlighted putatively as refugia. Limited mixing between adjacent geographical areas such as the Dry Valleys and Ross Island was identified, with migration likely to be influenced by wind currents.

This haplotype was nearly identical to haplotypes from as far afield as Svalbard showing a consistency in photobiont selection over a very wide geographical range and may be micro-climate specific. Other haplotypes present were specific to single geographical areas, and mutation may play the major role in this. Collectively, these findings suggest that despite potentially high dispersal of propagules, populations of lichen species in the Ross Dependency show differentiation among locations and are potentially limited in their dispersal to different habitats.

This may be the result of high selectivity for the photobiont. I conclude that lichen populations in the Ross Sea Region have originated from ancient, refugial populations rather than being populated via recent dispersal from northern continents. Dispersal within this region is likely to be restricted by ice-covered areas and relichenisation is potentially limited to particular photobiont strains which are suited to the micro-climatic conditions found in this region. Overview Human Genetics : This course will deal with ethical issues in the gathering, dissemination, and use of genetic information for decisions concerning reproduction, health care, and research.

New Research In

Overview Human Genetics : Principles and concepts of the genetics of human populations. Overview Human Genetics : A review of recent advances in human genomics and current state of the art technologies of DNA sequence and whole genomics analyses, as well as future directions in the post-genomic era.

follow url Overview Human Genetics : This course will deal with recent progress in human genetics, and its applications to health care, by identifying different fields including different disciplines e. Overview Human Genetics : The principles and practice associated with inherited predisposition to cancer breast and colon cancers, example such as the methods of gene discovery, clinical characteristics of inherited predisposition, methods of mutation analysis, genetic counselling, and ethical issues of genetic testing.

Intersection of genomics and epigenetics with experimentation

Overview Human Genetics : Introduction to advanced concepts of host resistance to infectious diseases as they apply to both animal models and human populations. Overview Human Genetics : Study of internet resources relevant to biomedical research. Overview Human Genetics : A seminar on current knowledge in the field of complex trait genetics as it applies to psychiatric disease. Overview Human Genetics : A review and discussion of specific topics in genetics genetic models: population-based, animal, and in vitro genetic models, genomics, and medical genetics centred on current literature and latest advances in the field.

Note: Course enrolment is limited to 12 students. Terms: Fall , Winter Instructors: There are no professors associated with this course for the academic year. Faculty of Medicine— last updated Aug. Faculty Links Medicine website Contact.